Award
National Institute of General Medical Sciences 5R35GM148339-04
Leveraging ubiquitin-dependent regulatory mechanisms to improve proteome quality in health and disease
Recipient
National Institute of General Medical Sciences (NIGMS), NIH, US
Award Amount
$590,920.00
Ceiling
$590,920.00
Awarded
February 09, 2026
Identifier
5R35GM148339-04
Award for research on ubiquitin ligases to improve proteome quality and address neurodegenerative disorders through molecular and cellular studies.
Description
This project focuses on molecular mechanisms to enhance proteostasis and combat aging-related neurodegenerative disorders. It involves structural, biochemical, and cellular studies of ubiquitin ligases, particularly HUWE1, and aims to develop strategies to modify cellular responses to proteotoxic stress.