Award
National Heart, Lung, and Blood Institute 1R01HL178722-01A1
Control of virus-induced lung sequelae by P2RX7-expressing CD4+ T cells
Recipient
Mayo Clinic Arizona, Scottsdale, AZ, United States
Award Amount
$1,665,204.00
Ceiling
$1,665,204.00
Awarded
July 14, 2026
Identifier
1R01HL178722-01A1
The project investigates how P2RX7-expressing lung CD4+ T cells contribute to lung damage after severe respiratory infections and tests if blocking P2RX7 can prevent or reverse lung sequelae.
Description
This project aims to define how sensing of the danger signal extracellular ATP via P2RX7 promotes the establishment of pathogenic lung tissue-resident helper CD4+ T cells, which in turn lead to long-term lung damage in response to influenza or SARS-CoV2.