Award
National Institute of Biomedical Imaging and Bioengineering 5R01EB032655-04
A novel paradigm of sensitization of the tumor microenvironment with image-guided ultrasound cavitation and mechanotherapeutics for targeted HCC treatment
Recipient
University of Washington, Seattle, WA, United States
Award Amount
$600,789.00
Ceiling
$600,789.00
Awarded
May 16, 2025
Identifier
5R01EB032655-04
This award funds research to develop and evaluate a novel image-guided treatment combining mechanotherapeutic drugs and ultrasound cavitation to improve drug delivery and treatment outcomes for hepatocellular carcinoma.
Description
The project aims to develop a novel image-guided approach for modulating the tumor microenvironment of hepatocellular carcinoma (HCC) using combined mechanotherapeutic drugs and ultrasound cavitation treatment, evaluating its therapeutic efficacy and implementing it on a clinical scanner for wider use. The goal is to enhance drug delivery and improve therapy outcomes by altering tumor pressure, stiffness, and vascular characteristics.