Award
NIH Reporter #5K08HL171943-02
Lymph Node Stromal Cells in the Pathogenesis, Diagnosis, and Treatment of Unicentric Castleman Disease
Recipient
University of Pennsylvania, Philadelphia, PA, United States
Award Amount
$164,860.00
Ceiling
$164,860.00
Awarded
September 08, 2026
Identifier
5K08HL171943-02
A five-year research project funded to study the role of lymph node stromal cells in Castleman Disease, aiming to develop new diagnostics and treatments by investigating cellular clonality and mutations.
Description
The project aims to study whether clonal activation of lymph node stromal cells contributes to Castleman Disease pathogenesis, with the goal of developing new diagnostic tools and therapies. The research will investigate somatic mosaicism of non-hematopoietic lymph node stromal cells, focusing on clonality and mutations such as PDGFRB, to advance diagnostics and therapies for Castleman Disease.