Award
National Cancer Institute 1R01CA310177-01
A microphysiological model of prostate cancer metastasis into vascularized and innervated bone
Recipient
Oregon Health & Science University
Award Amount
$521,002.00
Ceiling
$521,002.00
Awarded
March 31, 2026
Identifier
1R01CA310177-01
NIH grant awarded to Oregon Health & Science University to develop a bone metastasis-on-a-chip model for prostate cancer research, focusing on vascular and neural contributions to metastasis.
Description
This project develops an innovative bone metastasis-on-a-chip platform incorporating mineralized bone matrix, perfusable vasculature, and neural networks to study metastasis mechanisms in prostate cancer. It aims to elucidate how vascular mechanics and tumor-nerve signaling contribute to metastasis, providing a high-fidelity model for studying microenvironmental regulation across cancer types.