Award
National Cancer Institute 11294877
MTAP-MAT2A synthetic-lethality induced by transition state analogs
Recipient
Albert Einstein College of Medicine
Award Amount
$692,197.00
Ceiling
$692,197.00
Awarded
April 03, 2026
Identifier
11294877
NIH grant awarded to Albert Einstein College of Medicine for a study on MTAP-MAT2A synthetic lethality using transition state analogs to inhibit tumor growth, particularly in colorectal cancer.
Description
Research project focused on synthetic lethality in cancer therapy, targeting MTAP, MAT2A, and PRMT5 inhibitors with applications in colorectal cancer and other tumors. The project involves pharmacodynamics, toxicology, and preclinical models including human CRC organoids and xenografts.