Award
NIH Reporter #11381064
Mechanisms of Claudin-5 Regulation during Neuroinflammation
Recipient
University of South Florida
Award Amount
$400,599.00
Ceiling
$400,599.00
Awarded
July 15, 2026
Identifier
11381064
The award supports research investigating the roles of FoxO1, nmMLCK, and HDAC6 in blood-brain barrier dysfunction during neuroinflammation, focusing on multiple sclerosis, with the goal of identifying new therapeutic targets.
Description
This project aims to define cellular and molecular mechanisms by which molecules FoxO1, nmMLCK, and HDAC6 contribute to the loss of tight junction protein claudin-5 in blood-brain barrier endothelial cells and to evaluate therapeutic strategies to restore BBB integrity and limit disease progression using animal and cell culture models of multiple sclerosis.