Award
NIH Reporter #5R01CA272484-05
Dynamics of Notch Signaling
Recipient
Harvard Medical School
Award Amount
$661,179.00
Ceiling
$661,179.00
Awarded
August 31, 2026
Identifier
5R01CA272484-05
NIH awarded $661,179 to Harvard Medical School for a project on the dynamics of Notch signaling, aiming to study molecular events and mechanisms using advanced imaging technologies from 2022 to 2027.
Description
This NIH project aims to elucidate the molecular mechanisms of Notch signaling using cutting-edge imaging and labeling technologies. The project focuses on the molecular events of Notch signaling, which influences cell differentiation in mammals and is associated with various diseases, including cancers. The work will utilize emerging technologies such as proximity labeling and lattice light sheet microscopy to achieve unprecedented resolution in space and time of Notch signal transmission in living cells.