Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 5R01AR080436-05
Interrogating unique DC adaptations to tissue to promote barrier immunity and tolerance
Recipient
Weill Medical College of Cornell University
Award Amount
$691,545.00
Ceiling
$691,545.00
Awarded
January 08, 2026
Identifier
5R01AR080436-05
This NIH grant supports research on tissue immune regulation, focusing on dendritic cell biology to improve vaccine, viral, and cancer immunity strategies.
Description
The project aims to understand how dendritic cells (DCs) develop uniquely and are adapted in tissues to perform and balance functions such as self-tolerance and pathogen surveillance. Recent discoveries include a new mechanism and molecular target dictating DC differentiation in tissues. The research will deepen understanding of DC biology, identify modifiable behaviors by local cues, and improve interventions during disease, advancing human health.