Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 5R01AR066053-10
Role of PTPRS in Rheumatoid Arthritis
Recipient
Cedars-Sinai Medical Center, Los Angeles, CA, United States
Award Amount
$411,931.00
Ceiling
$411,931.00
Awarded
April 22, 2025
Identifier
5R01AR066053-10
Research project funded by NIAMS to study the role of PTPRS in rheumatoid arthritis, aiming to validate it as a therapeutic target by investigating its regulation and effects on FLS cells.
Description
This project focuses on understanding the mechanism of action and regulation of the tyrosine phosphatase PTPRS, which influences fibroblast-like synoviocytes (FLS) migration and invasion in rheumatoid arthritis (RA). The research aims to deepen understanding of PTPRS regulation and its role in FLS-induced inflammation, with the goal of validating PTPRS as a therapeutic target for RA.