National Cancer Institute 11358491

THE INTEGRATED STRESS RESPONSE IN GBM PATHOGENESIS AND RESPONSE TO THERAPY

Research project funded by the National Cancer Institute to study the integrated stress response in glioblastoma, focusing on molecular mechanisms and therapy response using animal models.

Description

The project focuses on the role of the integrated stress response (ISR) in glioblastoma (GBM) pathogenesis and therapy response. The study aims to define the role of eIF2B in translational regulation, tumor growth, and therapy response. Investigates translational reprogramming mechanisms and targeted therapies involving aminoacyl-tRNA synthetases. Uses animal models due to limitations of cell culture and in silico models. Funding is from the National Cancer Institute (NCI), part of NIH. The project involves multiple aims including defining molecular mechanisms and testing therapeutic strategies.

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