Award
NIH Reporter #5K08AI180429-02
The Role of ADAM9 in the Innate Immune Response to SARS-CoV-2 Infection
Recipient
University of Massachusetts Medical School Worcester, MA
Award Amount
$190,058.00
Ceiling
$190,058.00
Awarded
December 08, 2025
Identifier
5K08AI180429-02
A research project funded to investigate the role of ADAM9 in the innate immune response to SARS-CoV-2, focusing on immune dysregulation and lung injury in severe COVID-19 cases.
Description
This project aims to define ADAM9's role in the immunopathogenesis of severe COVID-19 and its impact on SARS-CoV-2-induced acute lung injury. The study focuses on the ADAM9/MDA5 pathway and its role in immune dysregulation and lung pathology, building on previous research and preliminary data. The project is conducted at UMass Chan Medical School, Worcester, MA, and is supported by mentorship and career development mechanisms.