Award
NIH Reporter #3R01CA164719-12S1
Anti-cancer vaccine targeting the host-parasite interface during fluke infection
Recipient
George Washington University
Award Amount
$56,808.00
Ceiling
$56,808.00
Awarded
September 18, 2025
Identifier
3R01CA164719-12S1
Development of a vaccine to prevent liver fluke infection and associated bile duct cancer in endemic regions of East Asia by targeting essential parasite proteins.
Description
The project aims to develop an anti-infection/anti-cancer vaccine targeting proteins essential to the parasite Opisthorchis viverrini, which causes liver fluke infection linked to cholangiocarcinoma (bile duct cancer) in East Asia. The vaccine targets key proteins involved in the parasite's communication with the host and its pathogenic mechanisms to reduce fluke burdens and cancer incidence.