Award
National Institute on Aging 5R01AG071782-05
Compromised function of a glial glucose transporter in aging and Alzheimer's disease
Recipient
University of Arkansas for Medical Sciences, Little Rock, AR, United States
Award Amount
$372,400.00
Ceiling
$372,400.00
Awarded
December 19, 2024
Identifier
5R01AG071782-05
Research project studying how impaired glucose transport in brain cells contributes to Alzheimer's disease and aging-related cognitive decline, aiming to find therapeutic strategies.
Description
This project investigates the link between circulating glucose metabolism and age-related processes in brain support cells, particularly astrocytes, and their role in Alzheimer's disease (AD). It hypothesizes that amyloid beta (Aβ) disrupts glucose transport in astrocytes, impairing neuronal energy supply and contributing to cognitive decline. The study involves genetic modification of mice to modulate astrocytic glucose transporter levels and assess impacts on glucose delivery and memory deficits, aiming to identify potential therapeutic strategies.