Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK136237-04
Placental Insulin Signaling and mTOR Nutrient-Sensing Programming of Offspring Metabolic Health
Recipient
University of Minnesota, Minneapolis, MN
Award Amount
$521,795.00
Ceiling
$521,795.00
Awarded
February 16, 2026
Identifier
5R01DK136237-04
Research project funded by NIDDK to study the impact of maternal insulin levels on placental nutrient delivery and offspring metabolic health using genetic models.
Description
This project aims to understand how high maternal insulin during pregnancy affects placental nutrient delivery and offspring metabolic health, focusing on insulin receptor (IR), insulin-like growth factor 1 receptor (IGF1R), mTOR, and GLUT4 signaling pathways. It addresses the role of insulin signaling in placental function and the mechanistic link between maternal hyperinsulinemia and the programming of metabolic disease in offspring.