National Institute of Neurological Disorders and Stroke 5K23NS124688-04

Mechanisms of Gait and Balance Impairment in Progressive Supranuclear Palsy

NIH awarded a research grant to Mayo Clinic Rochester to study gait and balance impairments in progressive supranuclear palsy using motion capture and neuroimaging to improve diagnosis and treatment.

Description

This project aims to describe objectively quantifiable metrics of gait and balance impairment in progressive supranuclear palsy (PSP) and determine the underlying mechanisms using advanced neuroimaging. The work will improve understanding of PSP, identify those at risk for falls, and evaluate treatments to reduce death and disability from falls. The study will utilize laboratory-based motion capture and body-worn motion sensing devices to identify gait metrics that characterize PSP syndromes and distinguish PSP from normal controls. It will correlate gait and balance metrics with volumetric MRI, diffusion MRI, and tractography to analyze neurobiological mechanisms underlying gait and balance impairment. The project will also assess the impact of sex and age on gait abnormalities.

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