Award
National Cancer Institute 5K08CA255465-05
Immunomodulatory Effects of Targeting DNA Repair with Novel Temozolomide Combinations in Colorectal Cancer
Recipient
Yale University
Award Amount
$260,958.00
Ceiling
$260,958.00
Awarded
July 11, 2025
Identifier
5K08CA255465-05
NIH-funded research project at Yale University investigating novel temozolomide combinations targeting DNA repair to improve immunotherapy outcomes in colorectal cancer.
Description
This project aims to develop novel strategies to improve clinical outcomes for colorectal cancer patients by targeting DNA repair mechanisms and immune responses. It focuses on the role of DNA repair pathways, such as MGMT methylation and base excision repair, in colorectal cancer and explores the use of temozolomide combined with PARP and ATR inhibitors to enhance therapeutic efficacy. The study also aims to develop biomarker assays and investigate the immune microenvironment's response to these therapies.