Award
National Heart, Lung, and Blood Institute 1R01HL180294-01
Excess cardiovascular inflammation in TB and HIV: EXFIN-TB
Recipient
University of Pennsylvania, Philadelphia, PA, United States
Award Amount
$2,513,201.00
Ceiling
$2,513,201.00
Awarded
August 29, 2025
Identifier
1R01HL180294-01
The EXFIN-TB study investigates how tuberculosis (TB) promotes cardiovascular inflammation and disease, particularly in patients with and without HIV. It aims to identify high-risk patients and understand inflammatory pathways to reduce post-TB cardiovascular disease.
Description
This project aims to characterize clinical risk factors and inflammatory pathways associated with cardiovascular disease in TB survivors, focusing on pulmonary inflammation, arterial stiffness, and inflammasome activity. It involves a prospective cohort study with parallel groups including TB patients with and without HIV, as well as community controls.