Award
National Institute on Aging 1R21AG089957-01
Age, sex, hormonal status, and anti-inflammatory therapy for atherosclerosis
Recipient
Saint Louis University, MO, United States
Award Amount
$416,625.00
Ceiling
$416,625.00
Awarded
July 18, 2024
Identifier
1R21AG089957-01
This award funds research investigating how age, sex, and hormonal status affect atherosclerosis and tests a novel anti-inflammatory therapy using pulsed low-dose RANKL in mice. The study aims to identify new mechanisms and potential treatments for cardiovascular disease, especially in aging and post-menopausal populations.
Description
The project focuses on the impact of age, sex, and hormonal status on atherosclerosis. It proposes to test a novel therapeutic approach using pulsed low-dose RANKL to induce plaque resident regulatory T-cells that secrete IL-10, aiming to create an anti-inflammatory, pro-resolving environment in plaques to protect against atherosclerosis. The research involves comprehensive transcriptomic profiling at a single-cell level to understand inflammatory cell clusters and mechanisms of plaque stability and vulnerability.