Award
NIH Reporter #5R01AI167880-04
Redox Regulation of DksA-dependent Borrelia burgdorferi infectivity
Recipient
Creighton University
Award Amount
$436,962.00
Ceiling
$436,962.00
Awarded
July 30, 2026
Identifier
5R01AI167880-04
The award supports research on the role of DksA in regulating gene expression in Borrelia burgdorferi in response to oxidative stress, which is critical for Lyme disease infectivity and transmission.
Description
This project aims to understand how DksA senses oxidative stress in tick and mammalian environments to regulate gene expression, contributing to strategies for preventing Lyme disease by targeting bacterial sensing mechanisms.