Award
National Institute of Neurological Disorders and Stroke 5R01NS073899-14
The hsp90 Cochaperone FKBP51 Regulates tau Structure and Function
Recipient
University of South Florida, Tampa, FL
Award Amount
$678,953.00
Ceiling
$678,953.00
Awarded
February 25, 2026
Identifier
5R01NS073899-14
Research project funded by NINDS to study the role of FKBP51 in tau protein accumulation and neuropsychiatric symptoms in Alzheimer's disease using transgenic mouse models.
Description
This project will use transgenic mouse models to determine if removing or inhibiting FKBP51 can be protective against tau accumulation. It will also study whether mice with this risk variant are more vulnerable to neuropsychiatric symptoms. The work aims to validate FKBP51 as a target and characterize the molecular landscape associated with vulnerability to neuropsychiatric symptoms in tauopathies.