Award
National Heart, Lung, and Blood Institute 5R01HL174785-03
A Contrast-free Ultrasound-based Quantitative Angio Flow Imaging Technique to Assess Peripheral Arterial Disease of Lower Limb
Recipient
Mayo Clinic Rochester
Award Amount
$716,321.00
Ceiling
$716,321.00
Awarded
August 06, 2026
Identifier
5R01HL174785-03
NIH awarded a research grant to Mayo Clinic Rochester to develop a noninvasive ultrasound tool for early diagnosis and monitoring of peripheral arterial disease without using contrast agents.
Description
This project aims to develop a low-cost, noninvasive ultrasound-based tool called Angio Flow Reactivity Analysis (AFRA) for imaging microvascular changes associated with peripheral arterial disease (PAD). The technique does not require contrast agents and involves processing ultrasound data to estimate blood flow signals in the calf muscle, analyzing flow variations in response to external pressure and exercise. The goal is to enable early diagnosis, monitor disease progression, and assess response to treatment in PAD patients.