Award
NIH Reporter #11320762
PBRM1 bromodomain missense mutations in ccRCC vascular signaling
Recipient
National Cancer Institute (NCI), part of the NIH, United States
Award Amount
$52,204.00
Ceiling
$52,204.00
Awarded
May 01, 2026
Identifier
11320762
Award for research on the biochemical impacts of PBRM1 bromodomain missense mutations in ccRCC, focusing on protein stability, histone binding, and tumor signaling pathways involving HIF-2α and angiogenesis.
Description
This project aims to elucidate the biochemical impacts of ccRCC-associated PBRM1 bromodomain missense mutations on protein stability and histone binding, and to determine the role of PBRM1 in regulating HIF-2α and angiogenesis pathways. It involves computational prediction, biophysical validation, and cellular assays to identify benign or deleterious mutations and their effects on tumor signaling pathways.