Award
National Institute on Deafness and Other Communication Disorders 5F31DC022526-02
How genome architecture controls Protocadherin gene choice at single-allele resolution
Recipient
National Institute on Deafness and Other Communication Disorders (NIDCD), part of the NIH
Award Amount
$47,789.00
Ceiling
$47,789.00
Awarded
July 18, 2025
Identifier
5F31DC022526-02
This NIH-funded project studies how genome architecture controls Protocadherin gene choice at single-allele resolution, aiming to understand neural circuit formation and implications for neuropsychiatric disorders.
Description
The project involves studying genome architecture and gene regulation in neurons, with implications for neurodevelopmental and neuropsychiatric disorders. The project aims to understand how 3D genome architecture influences Pcdh gene expression and neural circuit formation using advanced imaging and sequencing techniques, including ORCA and single-cell sequencing. It has potential implications for understanding disorders such as schizophrenia and autism.