Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 4R00HD109370-02
Reprogramming Double Negative T Cells to Combat Autoimmune Ovarian Failure and Ovarian Tumors
Recipient
University of Florida, Gainesville, FL
Award Amount
$248,976.00
Ceiling
$248,976.00
Awarded
April 10, 2026
Identifier
4R00HD109370-02
The project aims to understand and manipulate double-negative T cells (DNTs) to treat autoimmune ovarian failure and ovarian tumors by revealing their role in immune regulation and developing new cell-based therapies.
Description
This project will reveal how DNT cells preserve ovarian immune balance. It will uncover how these cells prevent autoimmunity but can also be engineered for ovarian tumor suppression. The findings will lead to new cell-based off-the-shelf treatments for autoimmune ovarian dysfunction and ovarian cancer.