Award
National Heart, Lung, and Blood Institute 1R15HL165328-01A1
Obesity-related hypertension: the contribution of PPAR gamma acetylation and asprosin
Recipient
National Heart Lung and Blood Institute
Award Amount
$428,400.00
Ceiling
$428,400.00
Awarded
June 12, 2023
Identifier
1R15HL165328-01A1
NIH/NHLBI awarded a grant to study the role of PPAR gamma acetylation and asprosin in obesity-related hypertension, aiming to find therapeutic targets for hypertension in obese patients.
Description
This project aims to elucidate mechanisms by which obesity increases arterial stiffness and blood pressure, focusing on PPAR gamma acetylation and asprosin pathways. The project involves in vivo, ex vivo, and in vitro approaches, and aims to identify PPAR gamma deacetylation as a therapeutic target for hypertension in obese patients.