Award
National Cancer Institute 5R37CA246175-07
Obesity, sedentary behaviors, and diet quality for prevention and early detection of early-onset colorectal neoplasia
Recipient
Washington University, Saint Louis, MO
Award Amount
$544,890.00
Ceiling
$544,890.00
Awarded
July 07, 2026
Identifier
5R37CA246175-07
Research project funded by the National Cancer Institute to study obesity, sedentary behavior, and diet quality as factors in early-onset colorectal cancer, aiming to improve prevention and early detection.
Description
This project investigates the role of mid-adulthood and early-life obesity, sedentary behaviors, and poor diet in increasing the risk of early-onset advanced adenoma and colorectal cancer (CRC). It aims to elucidate the etiology of early-onset CRC, explore microbial translocation/endotoxemia as a pathway, and evaluate pharmacological prevention strategies. The study leverages data from prospective cohorts, decision modeling, and qualitative stakeholder interviews to inform personalized prevention and early detection strategies.