Award
NIH Reporter #5R01DK138154-03
Defining the molecular determinants of inflammatory memory in the pancreas
Recipient
WEILL MEDICAL COLL OF CORNELL UNIV, NY, UNITED STATES
Award Amount
$506,546.00
Ceiling
$506,546.00
Awarded
May 22, 2026
Identifier
5R01DK138154-03
The award supports research to define the molecular basis of inflammatory memory in the pancreas, studying epigenetic changes and their impact on cell fate, with the goal of identifying therapeutic targets.
Description
This project aims to understand the molecular mechanisms of inflammatory memory in the pancreas and explore potential therapeutic targets to mitigate long-term consequences of inflammation. It focuses on the epigenetic memory of inflammation in pancreatic acinar cells, investigating AP-1 binding to chromatin, reversibility of epigenetic memory, and the role of IL-33 as a cell-extrinsic factor.