Award
National Institute of Neurological Disorders and Stroke 5R01NS080946-12
Role of DYRK1A/MNB in synaptic growth and function
Recipient
University of Southern California, Los Angeles, CA, United States
Award Amount
$522,439.00
Ceiling
$522,439.00
Awarded
July 14, 2026
Identifier
5R01NS080946-12
Research grant to study DYRK1A/MNB kinase's role in synaptic growth and function, with implications for neurodegenerative diseases.
Description
The project aims to investigate the role of DYRK1A/MNB kinase in synaptic growth and function, focusing on its regulation of autophagy and neuropeptide release at the synapse. Using Drosophila models, the research will explore phosphorylation pathways involved in neurodegenerative diseases such as Alzheimer’s, autism spectrum disorder, frontotemporal dementia, and amyotrophic lateral sclerosis.