Award
National Institute of Mental Health 5R01MH134797-03
Role of the brain-immune axis in neuropsychiatric disease
Recipient
University of Pennsylvania
Award Amount
$407,857.00
Ceiling
$407,857.00
Awarded
January 14, 2026
Identifier
5R01MH134797-03
This NIH-funded project investigates how brain-immune interactions and blood-brain barrier impairment contribute to neuropsychiatric diseases, aiming to develop immune therapies.
Description
The study of brain-immune interactions focusing on the blood-brain barrier's role in neuropsychiatric diseases, using a model of human genetic susceptibility (22q11.2 deletion syndrome). The research aims to define developmental phenotypes, assess blood-brain barrier impact on brain-immune responses, and identify immune therapeutic strategies.