Award
National Institute of Biomedical Imaging and Bioengineering 5R01EB032726-04
Engineered BacNav and BacCav for Improved Excitability and Contraction
Recipient
Duke University
Award Amount
$477,473.00
Ceiling
$477,473.00
Awarded
January 15, 2025
Identifier
5R01EB032726-04
NIH grant awarded to Duke University for developing gene therapies using engineered prokaryotic sodium and calcium channels to improve cardiomyocyte excitability and contraction, aiming to prevent sudden cardiac death and heart failure progression.
Description
This project focuses on developing gene therapies to improve heart function by engineering smaller prokaryotic sodium and calcium channels for delivery via AAV vectors, with promising preliminary results in animal models.