Award
NIH Reporter #PAR-19-070
Upregulated Norepinephrine Synthesis Capacity in Aging
Recipient
Brandeis University, Waltham, MA
Award Amount
$1,382,890.00
Ceiling
$1,382,890.00
Awarded
April 08, 2026
Identifier
PAR-19-070
Research project funded by the National Institute on Aging to study norepinephrine synthesis and its impact on cognitive resilience and Alzheimer's disease progression using advanced imaging techniques.
Description
The project investigates the relationship between norepinephrine synthesis capacity and locus coeruleus structure, and the role of elevated norepinephrine synthesis in cognitive resilience and resistance to tau pathology spread in aging and Alzheimer’s disease. It employs multimodal imaging techniques including MRI, PET scans, and plasma measures to understand individual differences in disease progression and explore norepinephrine’s role in disease resilience and resistance.