Award
National Heart, Lung, and Blood Institute 5F30HL170483-03
Mechanisms of Cell-Free Hemoglobin-Mediated Injury to the Pulmonary Endothelial Glycocalyx in Sepsis
Recipient
Vanderbilt University
Award Amount
$53,937.00
Ceiling
$53,937.00
Awarded
August 18, 2025
Identifier
5F30HL170483-03
Research project funded by the National Heart Lung and Blood Institute to study cell-free hemoglobin's role in sepsis-induced lung injury, focusing on oxidative stress and glycocalyx degradation, with the goal of developing new therapies.
Description
The project focuses on understanding the role of cell-free hemoglobin (CFH) in sepsis-related endothelial injury. The research aims to elucidate mechanisms involving oxidative stress and glycocalyx degradation. The project involves mechanistic studies in cultured cells and murine models and aims to develop new therapeutic approaches for sepsis-associated lung injury.