Award
National Cancer Institute 5R21CA288928-02
Mechanisms of Th17-DC immunotherapy for ovarian cancer
Recipient
University of Arkansas for Medical Sciences
Award Amount
$178,819.00
Ceiling
$178,819.00
Awarded
February 14, 2025
Identifier
5R21CA288928-02
Research project funded by the National Cancer Institute to study the immune mechanisms and effectiveness of Th17-DC vaccination in ovarian cancer treatment.
Description
This project investigates the efficacy of anti-PD-1/Th17-DC vaccination in ovarian cancer, focusing on the role of host B cell responses and the formation of tertiary lymphoid structures (TLS). The study aims to determine whether B cells are essential for the vaccine's effectiveness and how TLS correlates with therapeutic responses.