Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 5R01HD116839-03
A novel live biologic for the prevention and treatment of NEC-induced neurodevelopmental impairment
Recipient
Research Institute Nationwide Children's Hospital
Award Amount
$645,254.00
Ceiling
$645,254.00
Awarded
May 28, 2026
Identifier
5R01HD116839-03
NIH grant awarded to develop a probiotic treatment to prevent and treat neurodevelopmental impairment caused by neonatal necrotizing enterocolitis using Limosilactobacillus reuteri.
Description
This project develops a tunable probiotic delivery system using Limosilactobacillus reuteri (Lr) in a biofilm on microspheres, aiming to prevent NEC and neurodevelopmental impairment (NI). The research will optimize Lr pathways to prevent and treat NEC-induced NI, with potential to develop an FDA-approved probiotic for premature infants.