Award
National Institute on Drug Abuse 5R01DA052317-05
Mechanisms of dopaminergic dysfunction in substance use disorder
Recipient
Vanderbilt University, Nashville, TN
Award Amount
$485,019.00
Ceiling
$485,019.00
Awarded
July 29, 2025
Identifier
5R01DA052317-05
This award funds research to understand how cocaine-induced changes in dopamine signaling affect learning and behavior in cocaine use disorder, using optical tools in mice to study dopamine function.
Description
The project aims to define how drug-induced dysregulation in the dopamine system underlies deficits in processing rewarding and aversive events related to cocaine use disorder (CUD). It investigates dopamine signaling in the nucleus accumbens (NAc) core, its role in salience and learning, and how cocaine exposure alters these processes.