NIH Reporter #5R01AI183970-02

Mechanisms and means to improve HIV bnAb activity in vivo

NIH-funded research project at Dartmouth College to improve the antiviral activity of HIV broadly neutralizing antibodies through Fc engineering and antibody combinations, aiming to delay or prevent systemic viremia in vivo.

Description

A research project funded by NIH focusing on HIV vaccine and antibody research. The project involves in vivo and in vitro studies aiming to improve HIV broadly neutralizing antibody activity. The objective is to define and refine the means by which broadly neutralizing antibodies (bNAbs) can be used to restrict HIV replication in vivo using a stringent model to monitor their ability to delay or prevent systemic viremia in the context of seeded HIV infection. The project tests two strategies to enhance antiviral activity of bNAbs: Fc engineering and bNAb combinations, evaluated for effects on neutralization and effector function in vitro and in vivo.

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