Award
National Cancer Institute 1R01CA316617-01
Brain Microenvironment Calcium Channels Modulate Glioblastoma
Recipient
University of Virginia
Award Amount
$523,232.00
Ceiling
$523,232.00
Awarded
July 30, 2026
Identifier
1R01CA316617-01
NIH grant awarded to University of Virginia to study the role of T-Type calcium channels in glioblastoma tumor microenvironment and develop new therapies.
Description
This research will investigate the mechanisms by which Cav3 channels influence glioblastoma growth and microenvironment interactions. The study will utilize co-cultures, animal models with cell-specific Cav3.2 knockouts, and advanced transcriptomic analyses. Therapeutic strategies combining Cav3 blockers with other inhibitors will be tested in mouse models.