Award
National Institute of Allergy and Infectious Diseases (NIAID) 5R01AI165147-05
Structural characterization of Fab-dimerized glycan-reactive antibodies that neutralize HIV-1
Recipient
Duke University, Durham, NC, United States
Award Amount
$661,066.00
Ceiling
$661,066.00
Awarded
August 20, 2025
Identifier
5R01AI165147-05
The project focuses on understanding the structure and mechanisms of Fab-dimerized glycan-reactive antibodies that neutralize HIV-1, with implications for vaccine development and therapeutic antibody design.
Description
This grant aims to structurally characterize HIV-1 glycan shield targeting Fab-dimerized glycan reactive (FDG) antibodies. The study will define atomic level structures of novel FDG antibodies in complex with their HIV-1 Env epitopes, elucidate the structural determinants of FDG antibody evolution, and determine the structural basis for FDG antibody recognition of diverse Coronavirus (CoV) spikes.