Award
National Institute of General Medical Sciences 5R35GM130587-08
Theory and Modeling of Biomolecules and their Interactions
Recipient
University of Michigan at Ann Arbor
Award Amount
$832,004.00
Ceiling
$832,004.00
Awarded
April 07, 2026
Identifier
5R35GM130587-08
A research project funded by the National Institute of General Medical Sciences to develop computational methods and software for studying biomolecules and their interactions, including ligand-receptor binding and pH-dependent processes.
Description
This project aims to develop novel and versatile methods to study biological molecules and their interactions via computer simulation, focusing on small molecule interactions with biological receptors and pH-dependent mediation of important processes. The research involves theoretical and computational advancements, software development (notably CHARMM), and strategic collaborations to explore ligand-receptor interactions, enzyme redesign, and pH-modulated processes.