Award
National Institute on Aging 1R21AG084378-01
HIV-1 and Alzheimer’s disease: Comorbidity
Recipient
University of Texas Rio Grande Valley, Edinburg, TX, United States
Award Amount
$407,000.00
Ceiling
$407,000.00
Awarded
August 23, 2023
Identifier
1R21AG084378-01
This award supports research investigating how HIV infection may accelerate cognitive decline in Alzheimer's disease using mouse models, addressing the comorbidity of HIV and AD in aging populations.
Description
The project aims to investigate the impact of HIV on the onset and progression of Alzheimer's disease (AD) using mouse models infected with chimeric HIV. The central hypothesis is that HIV promotes cognitive decline in AD models. The study will employ behavioral, pharmacological, molecular biology, and biochemistry approaches to determine if HIV accelerates AD-related cognitive dysfunctions.