Award
NIH Reporter #5R01DE032623-03
Exposing synthetic lethal vulnerabilities in EBV-positive AIDS-NHL through novel replication dependency factors
Recipient
University of Florida, Gainesville, FL
Award Amount
$593,500.00
Ceiling
$593,500.00
Awarded
June 20, 2025
Identifier
5R01DE032623-03
The award funds research to investigate synthetic lethal vulnerabilities in EBV-positive AIDS-NHL by studying replication dependency factors, focusing on the role of ZC3H18 in lymphoma proliferation and potential targeted therapies.
Description
This project aims to understand how EBV rewires cellular DNA replication to facilitate cancer cell proliferation and identify vulnerabilities for targeted therapy in EBV-positive AIDS-related non-Hodgkin lymphomas.