Award
NIH Reporter #1K99DK143293-01A1
Investigating Autism-Related Gut Dysfunction with Human Enteric Neurons and Intestinal Organoids
Recipient
University of Southern California, Los Angeles, CA
Award Amount
$90,000.00
Ceiling
$90,000.00
Awarded
March 19, 2026
Identifier
1K99DK143293-01A1
A NIH-funded research project at the University of Southern California studying autism-related gut dysfunction through advanced stem cell and genomic techniques, focusing on enteric neurons and intestinal organoids to understand GI disorders in ASD.
Description
This project investigates the contribution of human enteric neurons and intestinal organoids to autism spectrum disorder-associated gastrointestinal dysfunction using human induced pluripotent stem cell-derived models. It aims to dissect cellular and molecular mechanisms underlying GI disorders in ASD, focusing on the role of ASD-associated genes such as SYNGAP1.