Award
NIH Reporter #5R01MH132689-03
Elucidating Regulation of Cell Fate Specification in Human Cortical Development to Understand Etiology of Neurodevelopmental Disorders
Recipient
University of California Los Angeles
Award Amount
$682,618.00
Ceiling
$682,618.00
Awarded
August 14, 2026
Identifier
5R01MH132689-03
This NIH-funded project by University of California Los Angeles studies the regulation of cell fate in human cortical development to understand neurodevelopmental disorders, using advanced bioinformatics and CRISPR techniques.
Description
The project aims to investigate the mechanisms of cortical arealization and laminar fate specification in the developing human brain, focusing on the role of transcription factors and terminal factors in the prefrontal cortex. Using bioinformatics and CRISPR activation screens, the study will explore signals that drive cortical arealization and laminar identity, with implications for understanding neurodevelopmental disorders.