Award
National Institute on Drug Abuse 5DP1DA058385-04
Development of High-Affinity and Selective Ligands as a Pharmacological Tool for the Dopamine D4 Receptor (D4R) Subtype Variants
Recipient
HIGH POINT UNIVERSITY
Award Amount
$447,000.00
Ceiling
$447,000.00
Awarded
March 23, 2026
Identifier
5DP1DA058385-04
This NIH-funded project by High Point University focuses on developing selective ligands for dopamine D4 receptor variants to understand their role in neuropsychiatric disorders and create potential therapeutics for substance use disorders.
Description
The project aims to discover candidate medications and develop new molecular tools to study the dopamine D4 receptor (D4R) and its variants, specifically the D4.4R and D4.7R variants associated with ADHD and substance use disorders. The research involves designing, synthesizing, and evaluating new ligands using computational modeling to develop selective D4R ligands for therapeutic use.