Award
National Cancer Institute 2R01CA190394-11A1
Targeting the cytokine circuitry of KRAS driven lung cancer
Recipient
Dana-Farber Cancer Institute, Boston, MA, United States
Award Amount
$460,600.00
Ceiling
$460,600.00
Awarded
April 06, 2026
Identifier
2R01CA190394-11A1
Research project focused on developing novel immunotherapeutic strategies targeting KRAS-driven lung cancer by modulating innate immune signaling pathways, aiming to improve durable responses and clinical outcomes.
Description
This project proposes to study the cells that survive after KRAS targeted therapy, and to expose their vulnerability to the immune system by unleashing pathways that trigger strong anti-viral responses that can kill them. The studies have direct translational potential to lead to effective clinical trials in the future.