Award
National Institute of Allergy and Infectious Diseases 4R01AI135025-09
Mechanism, Function, and Exploitation of Influenza A Virus-Activated Cell Death
Recipient
RESEARCH INST OF FOX CHASE CAN CTR, PHILADELPHIA, PA, UNITED STATES
Award Amount
$1,460,069.00
Ceiling
$1,460,069.00
Awarded
August 28, 2025
Identifier
4R01AI135025-09
The award supports research on how Influenza A virus activates cell death pathways via ZBP1 and necroptosis, exploring mechanisms of viral pathogenesis and host defense, with implications for understanding influenza severity and evolution.
Description
This project investigates the cell death pathways activated by Influenza A virus (IAV), focusing on the role of ZBP1 sensing viral and host Z-RNAs, the mechanisms of necroptosis and apoptosis, and their impact on influenza pathogenesis, host defense, and viral evolution. The research aims to identify endogenous Z-RNA ligands for ZBP1, understand non-cytolytic ZBP1 signaling in alveolar macrophages, and elucidate nuclear necroptosis in influenza disease and evolution.