Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK136536-03
Regulation of brown fat fuel utilization by the malate-aspartate shuttle
Recipient
LSU PENNINGTON BIOMEDICAL RESEARCH CTR
Award Amount
$389,852.00
Ceiling
$389,852.00
Awarded
August 12, 2025
Identifier
5R01DK136536-03
This award supports research to understand how brown fat uses various fuels for heat production, focusing on the malate-aspartate shuttle and the enzyme GOT1's role in thermogenesis.
Description
The project aims to elucidate the mechanism that coordinates complex substrate utilization in brown adipose tissue (BAT) in response to cold or β3-adrenergic receptor stimulation. It focuses on the role of the malate-aspartate shuttle (MAS) and the enzyme GOT1 in supporting thermogenesis through metabolic coordination.