Award
National Institute of Neurological Disorders and Stroke 5R21NS141767-02
Peptide Nucleic Acid (PNA) Oligomers for Targeted Disruption of Biomolecular Condensates in ALS/FTD
Recipient
Carnegie Mellon University
Award Amount
$232,953.00
Ceiling
$232,953.00
Awarded
August 05, 2025
Identifier
5R21NS141767-02
Award for research on developing PNA oligomers to target biomolecular condensates in ALS/FTD, aiming to create tools for labeling and disrupting RNA condensates relevant to neurodegenerative diseases.
Description
This project involves developing peptide nucleic acid (PNA) probes to manipulate and monitor biomolecular condensates related to neurodegenerative diseases such as ALS and FTD. The research aims to develop tools that can label RNAs involved in condensates and disrupt their formation, with potential applications across various neurodegenerative conditions.