Award
National Institute of Neurological Disorders and Stroke 1RF1NS144213-01
SARS-CoV-2 initiation and acceleration of AD pathology in the setting of endogenous and exogenous risk factors
Recipient
Baylor College of Medicine
Award Amount
$3,039,032.00
Ceiling
$3,039,032.00
Awarded
August 14, 2025
Identifier
1RF1NS144213-01
NIH grant awarded to Baylor College of Medicine to study the role of SARS-CoV-2 in Alzheimer's disease pathology using mouse models and novel imaging, focusing on genetic and viral risk factors.
Description
This NIH grant project hypothesizes that SARS-CoV-2 may contribute to the cascade leading to Alzheimer's disease and related dementias. It aims to conduct phenotyping and mechanistic studies in mouse models, utilizing novel imaging methodologies, to characterize neuropathological changes post-COVID-19 and uncover mechanistic links. The study will explore the relative contributions of genetic risk factors and COVID-19, effects of SARS-CoV-2 variants, and prior infections with other viruses like HSV-1 on AD/RD initiation and progression.